Coden: Ijpnl6 Evaluation of Antiulcer Activity of Plant Chrozophora Plicata

The herbal medicines derived from various plants extracts are being increasingly utilized to treat a wide variety of clinical diseases 1 . Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers 2 . The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) against experimentally induced ulcer models in albino rats. In the present study, anti-ulcer activity was assessed by using pylorus ligation induced and indomethacin (40mg/kg) induced Ulcer 3 models in albino rats. The antiulcer activity was assessed by determining and comparing gastric volume, acidity, ulcer score and ulcer index in control, test extract and standard (ranitidine 10mg/kg) treated rats by using both pylorus ligation and indomethacin induced ulcer models. Pre-treatment of animals with the Chloroform extract of Chrozophora plicata (600mg/kg)) orally significantly reduced formation of ulcers induced by pylorus ligation and indomethacin models. The percentage inhibitions of ulcer with test extract being 60 ±1.12 % and 57.18 ± 1.32 % respectively whereas standard ranitidine has shown percentage inhibitions of ulcer to an extent of 100± 0.42% and 68.52±1.07% in both ulcer models. It is evident from literature that Chrozophora plicata leaves possess flavonoids 4 . The results obtained indicate that Chrozophora plicata possesses antiulcer principles.